Human fear conditioning: From neuroscience to the clinic

MA Fullana; JE Dunsmoor; KRJ Schruers; HS Savage; DR Bach; BJ Harrison

Journal article

Human fear conditioning: From neuroscience to the clinic

MA Fullana, JE Dunsmoor, KRJ Schruers, HS Savage, DR Bach, BJ Harrison

Behaviour Research and Therapy | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020

DOI: 10.1016/j.brat.2019.103528

Abstract

Both clinicians and neuroscientists have been long interested in the topic of fear conditioning, with recent advances in neuroscience, in particular, igniting a shared interest in further translation between these domains. Here, we review some historical aspects of this relationship and the progress that has been made in translating the neuroscientific study of fear conditioning to the conceptualization and treatment of mental disorders, especially anxiety-related disorders. We also address some conceptual and methodological challenges faced by this research, and offer some suggestions to support future progress in the field.

University of Melbourne Researchers

Ben Harrison Author

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Grants

Awarded by National Science Foundation

Funding Acknowledgements

MAF is supported by Carlos III Health Institute and FEDER grant (PI16/00144). JED is supported in part from NIH R00MH106719 and a National Science Foundation CAREER award (1844792). HSS is supported by an Australian Government Research Training Program (RTP) Scholarship. DRB is supported by funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. ERC-2018 CoG-816564 ActionContraThreat). BJH is supported by a NHMRC Career Development Fellowship (1124472), and acknowledges additional funding support from NHMRC Project Grants (1161897; 1145010).